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Design and Nanofabrication of Highly Sensitive Plasmonic Sensors for Biomedical Cell and Molecule Detection
Health & Wellness
Biomedical and Genetic Engineering
Nanotechnology and New Materials
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Opportunity Compact system suitable for point-of-care applications User-friendly operation, eliminating the need for medical personnel Cost-effective nanoimprint technology, facilitating mass production Highly sensitive biosensors for unique detection of nanometer-sized biomolecules Enables early disease detection and diagnosis Applicable to a variety of diseases Technology The invention features an engineered platform equipped with an array of plasmonic sensors on a base, serving as a biosensor for cell and biomolecule detection. Additionally, a separator is positioned atop the biosensors to distinguish cell protrusions from cell bodies, enabling the detection of nanometer-sized filopodia separated from micrometer-sized cell bodies for the first time Compact microfluidic system Nanoimprint technology for stacking multiple layers Plasmonic sensor for nanometer-sized biomolecule detection Separator to distinguish micrometer-sized cell bodies from nanometer-sized cell protrusions First time sensing of filopodia from cells for disease screening and cancer diagnosis Advantages First time demonstration of biosensing at nanometer dimensions  High sensitivity due to advanced plasmonic sensors  Compact microsystem that can be mass produced at low cost  The only microfluidic system capable of distinguishing cell protrusions from cell bodies  Low noise system for detection based on shift of resonance peaks  Applications Compact, user-friendly, portable microsystem for point-of-care applications   High-sensitivity biosensor for early disease screening and diagnosis  Cost-effective production of plasmonic detector in integrated microfluidic system  Detection of nanometer-sized filopodia and biomolecules  Applicable to multiple diseases, including cancer 
Opportunity Compact system suitable for point-of-care applications User-friendly operation, eliminating the need for medical personnel Cost-effective nanoimprint technology, facilitating mass production Highly sensitive biosensors for unique detection of nanometer-sized biomolecules Enables early disease detection and diagnosis Applicable to a variety of diseases Technology The invention features an engineered platform equipped with an array of plasmonic sensors on a base, serving as a biosensor for cell and biomolecule detection. Additionally, a separator is positioned atop the biosensors to distinguish cell protrusions from cell bodies, enabling the detection of nanometer-sized filopodia separated from micrometer-sized cell bodies for the first time Compact microfluidic system Nanoimprint technology for stacking multiple layers Plasmonic sensor for nanometer-sized biomolecule detection Separator to distinguish micrometer-sized cell bodies from nanometer-sized cell protrusions First time sensing of filopodia from cells for disease screening and cancer diagnosis Advantages First time demonstration of biosensing at nanometer dimensions  High sensitivity due to advanced plasmonic sensors  Compact microsystem that can be mass produced at low cost  The only microfluidic system capable of distinguishing cell protrusions from cell bodies  Low noise system for detection based on shift of resonance peaks  Applications Compact, user-friendly, portable microsystem for point-of-care applications   High-sensitivity biosensor for early disease screening and diagnosis  Cost-effective production of plasmonic detector in integrated microfluidic system  Detection of nanometer-sized filopodia and biomolecules  Applicable to multiple diseases, including cancer 
Opportunity Compact system suitable for point-of-care applications User-friendly operation, eliminating the need for medical personnel Cost-effective nanoimprint technology, facilitating mass production Highly sensitive biosensors for unique detection of nanometer-sized biomolecules Enables early disease detection and diagnosis Applicable to a variety of diseases Technology The invention features an engineered platform equipped with an array of plasmonic sensors on a base, serving as a biosensor for cell and biomolecule detection. Additionally, a separator is positioned atop the biosensors to distinguish cell protrusions from cell bodies, enabling the detection of nanometer-sized filopodia separated from micrometer-sized cell bodies for the first time Compact microfluidic system Nanoimprint technology for stacking multiple layers Plasmonic sensor for nanometer-sized biomolecule detection Separator to distinguish micrometer-sized cell bodies from nanometer-sized cell protrusions First time sensing of filopodia from cells for disease screening and cancer diagnosis Advantages First time demonstration of biosensing at nanometer dimensions  High sensitivity due to advanced plasmonic sensors  Compact microsystem that can be mass produced at low cost  The only microfluidic system capable of distinguishing cell protrusions from cell bodies  Low noise system for detection based on shift of resonance peaks  Applications Compact, user-friendly, portable microsystem for point-of-care applications   High-sensitivity biosensor for early disease screening and diagnosis  Cost-effective production of plasmonic detector in integrated microfluidic system  Detection of nanometer-sized filopodia and biomolecules  Applicable to multiple diseases, including cancer 

 

Opportunity

This microfluidic apparatus comprises an array of highly sensitive plasmonic biosensors and a separator, designed to detect nanometer-sized protrusions from cells, facilitating effective disease screening and diagnosis.

  • Compact system suitable for point-of-care applications
  • User-friendly operation, eliminating the need for medical personnel
  • Cost-effective nanoimprint technology, facilitating mass production
  • Highly sensitive biosensors for unique detection of nanometer-sized biomolecules
  • Enables early disease detection and diagnosis
  • Applicable to a variety of diseases

Technology

The invention features an engineered platform equipped with an array of plasmonic sensors on a base, serving as a biosensor for cell and biomolecule detection. Additionally, a separator is positioned atop the biosensors to distinguish cell protrusions from cell bodies, enabling the detection of nanometer-sized filopodia separated from micrometer-sized cell bodies for the first time.

  • Compact microfluidic system
  • Nanoimprint technology for stacking multiple layers
  • Plasmonic sensor for nanometer-sized biomolecule detection
  • Separator to distinguish micrometer-sized cell bodies from nanometer-sized cell protrusions
  • First time sensing of filopodia from cells for disease screening and cancer diagnosis
  • Compact system suitable for point-of-care applications

Advantages

  • First time demonstration of biosensing at nanometer dimensions 
  • High sensitivity due to advanced plasmonic sensors 
  • Compact microsystem that can be mass produced at low cost 
  • The only microfluidic system capable of distinguishing cell protrusions from cell bodies 
  • Low noise system for detection based on shift of resonance peaks 

Applications

  • Compact, user-friendly, portable microsystem for point-of-care applications  
  • High-sensitivity biosensor for early disease screening and diagnosis 
  • Cost-effective production of plasmonic detector in integrated microfluidic system 
  • Detection of nanometer-sized filopodia and biomolecules 
  • Applicable to multiple diseases, including cancer 
Remarks
1. International Exhibition of Inventions of Geneva (IEIG) 2024 - Gold Medals with Congratulations of the Jury
2. International Exhibition of Inventions of Geneva (IEIG) 2024 - Special Award
IP Status
Patent granted
Technology Readiness Level (TRL)
6
Inventor(s)
Dr. ZHU Shuyan
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Design and Nanofabrication of Highly Sensitive Plasmonic Sensors for Biomedical Cell and Molecule Detection

 

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