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Prof. WANG Lidai and Prof. ZHU Guangyu in the Department of Chemistry developed “sono-sensitized chemotheraphy” (SSCT), which is a new form of ultrasound-activated chemotherapy, to further enhance the precision for eradicating deeper tumours with centimetre range of tissue penetration and minimizes side effects.

The research team invented the SSCT technique by developing cyaninplatin. The ultrasound-activated cyaninplatin can effectively induce cancer cell oxidation, eventually leading to mitochondrial DNA damage and cancer cell death.

The team’s work has been described and published in Science Advances under the title “An Ultrasound-Activatable Platinum Prodrug for Sono-Sensitized Chemotherapy”. (https://www.science.org/doi/10.1126/sciadv.adg5964).

Press coverage:
(13 OCT 2023) 深層腫瘤治療新方向 城大研超聲波激活抗癌化療 [Headline Daily]
(13 OCT 2023) 聲敏化療穿透力大 治深層腫瘤效佳 [Oriental Daily News]
(12 OCT 2023) Ultrasound-activated chemotherapy advances therapeutic potential for deep tumours [CityU Research Stories]
(12 OCT 2023) 城大研「聲敏化療」助治療深層腫瘤減少副作用 [dot dot news]
(12 OCT 2023) 城大研發以超聲波激活抗癌化療 [Hong Kong Economic Journal]